Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation
作者: Roger Sachan Panupong Jaipan Jennifer Y. Zhang Simone Degan Detlev Erdmann Jonathan Tedesco Lyndsi Vanderwal Shane J. Stafslien Irina Negut Anita Visan Gabriela Dorcioman Gabriel Socol Rodica Cristescu Douglas B. Chrisey Roger J. Narayan
刊名: International Journal of Bioprinting, 2017, Vol.3 (2)
来源数据库: Whioce Publishing Pte. Ltd
DOI: 10.18063/IJB.2017.02.004
关键词: matrix-assisted pulsed laser evaporationmicroneedleamphotericin Bantifungal
原始语种摘要: Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentrationdependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex...
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关键词翻译
关键词翻译
  • amphotericin 两性霉素
  • assisted 辅助的
  • evaporation 蒸发
  • matrix 石基
  • pulsed 脉冲
  • albicans 白的
  • against 反对
  • loaded 加负荷的
  • solubility 溶度
  • lithography 石版印刷