A Novel Monoclonal Antibody PC322 Inhibit Prostate Cancer Cell Autophagy
作者: Xing Kang1 Xu Zhang1 Xuejia Zhu1 Yuhan Yan2 Chong Li1345*
刊名: Cancer+, 2019, Vol.1 (1)
来源数据库: Whioce Publishing Pte. Ltd
DOI: 10.18063/c+.v1i1.214
关键词: Prostate cancerMonoclonal antibodyAutophagyAutophagosomesATG3
原始语种摘要: Autophagy is an important element in tumor progression. The clinical and commercial success of monoclonal antibodies (MAbs) for cancer has emerged as the fastest growing therapy. Prostate cancer is well appropriately suited for antibody therapy. PC322 is our newly prepared prostate cancer monoclonal antibody. In our current study, we described the impacts of PC322 on autophagy and biological behaviors in vitro and explored the possible mechanism of PC322 in prostate cancer cell autophagy. Role of PC322 on autophagy of LNCaP and C4-2 cells was observed with fluorescence microscopy, western blotting, and flow cytometry. Further, the function of PC322 on biological behaviors of prostate cancer cells was detected by CCK-8 kit, Hoechst 33342, wound healing assay and cell adhesion assay....
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  • antibody 抗体
  • monoclonal 单细胞系的
  • Antibody 抗体
  • blotting 浸透
  • autophagy 自体消瘦
  • prostate 前列腺
  • stimulation 激励
  • inhibited 被禁止
  • expression 表示
  • inhibiting 抑制