A dual crosslinking strategy to tailor rheological properties of gelatin methacryloyl
作者: Miaomiao Zhou Bae Hoon Lee Lay Poh Tan
刊名: International Journal of Bioprinting, 2017, Vol.3 (2)
来源数据库: Whioce Publishing Pte. Ltd
DOI: 10.18063/IJB.2017.02.003
关键词: microbial transglutaminaseenzymatic crosslinkingphoto crosslinkingviscosity
原始语种摘要: 3D bioprinting is an emerging technology that enables fabrication of three-dimensional organised cellular constructs. One of the major challenges in 3D bioprinting is to develop a material to meet the harsh requirements (cell-compatibility, printability, structural stability post-printing and bio-functionality to regulate cell behaviours) suitable for printing. Gelatin methacryloyl (GelMA) has recently emerged as an attractive biomaterial in tissue engineering because it satisfies the requirements of bio-functionality and mechanical tunability. However, the poor rheological property such as low viscosity at body temperature inhibits its application in 3D bioprinting. In this work, an enzymatic crosslinking method triggered by Ca2+-independent microbial transglutaminase (MTGase) was...
全文获取路径: Whioce Publishing  (合作)

  • crosslinking 交联
  • gelatin 
  • biomaterial 生物材料
  • rheological 流变学的
  • tailor 设计
  • enzymatic 酶催的
  • viscosity 粘度
  • constructs 建筑图纸生成系统
  • compatibility 相容性
  • stabilize 稳定