Inhibition of cancer cell proliferation by adenosine triphosphate-triggered codelivery system of p53 gene and doxorubicin
作者: Yong Liu Xinxin Shao Zhiyuan Shi Quanshun Li
刊名: Cancer+, 2019, Vol.1 (2)
来源数据库: Whioce Publishing Pte. Ltd
DOI: doi: 10.18063/c+.v1i2.239
关键词: ATP responseAptamerDoxorubicinP53 geneCo-delivery
原始语种摘要: The codelivery of drugs and genes by stimuli-responsive nanocarriers is a promising strategy for achieving an effective cancer treatment. In this study, an adenosine triphosphate (ATP)-responsive nanosystem was constructed to codeliver doxorubicin (DOX) and p53 gene based on an ATP-triggered aptamer and polyethyleneimine (PEI). In this system, DOX interacts with the GC-rich motif of duplex formed by the aptamer and its cDNA sequence. Then, a ternary nanocomplex DOX-Duplex/PEI/p53 was constructed using cationic carrier PEI25K for facilitating the intracellular delivery and release of p53 gene and DOX. The DOX-Duplex/PEI/p53 nanocomplex was found to possess an efficient anticancer effect, which was attributed to the ability of the system to trigger cell apoptosis and meanwhile block the...
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  • triggered 触发的
  • system 
  • doxorubicin 阿霉素
  • triphosphate 三磷酸盐
  • concentration 浓度
  • duplex 全双工
  • effect 效应
  • responsive 承担责任
  • cationic 阳离子的
  • cDNA 互补 DNA