In Vitro Antibacterial Activity of Galla Chinensis Combined with Different Antibacterial Drugs against Carbapenem-Resistant E.Coli
作者: XieZhizhi,XuChangzhi,YiYanhua,ZhuDonglin,XiYun
刊名: Journal of Advances in Medicine Science, 2019, Vol.2 (4)
来源数据库: Bilingual Publishing Co.
DOI: 10.30564/jams.v2i4.1229
关键词: Galla chinensisCarbapenem resistanceEscherichia coliCombination therapy
原始语种摘要: Objective: To evaluate the antibacterial effects of meropenem and levofloxacin respectively combined with Galla chinensis on carbapenem-resistant Escherichia coli in vitro. Methods: The protocol was designed with checkerboard method and the carbapenem-resistant E.coli was isolated in our hospital. The minimum inhibitory concentrations(MICs) of G. chinensis alone and combined with 2 antimicrobial agents against carbapenem-resistant E.coli were determined by broth dilution method and the fractional inhibitory concentration index (FICI) was calculated according to MICs results. Result: the combined use of G. chinensis and meropenem (or levofloxacin) significantly decreased both MIC50 and MIC90; After the combination of G. chinensis and meropenem, the synergistic effect was 86.7%, and the...
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  • Galla 盖拉族
  • against 反对
  • carbapenem 氨基甲酰
  • resistant 耐久的
  • combined 组合
  • effect 效应
  • antibacterial 抗细菌的
  • concentrations 浓聚物
  • Escherichia 埃希氏菌属
  • synergistic 协同的