Lack of Association between the 4234G/C X-Ray Repair Cross- Complementing 2 ( XRCC2 ) Gene Polymorphism and the Risk of Endometrial Cancer among Polish Population
作者: Hanna Romanowicz Magdalena Bryś Ewa FormaBeata Smolarz
刊名: Journal of Gynecological Research and Obstetrics, 2016, Vol.2 (1), pp.047-050
来源数据库: Peertechz Publications Private Limited
DOI: 10.17352/jgro.000018
原始语种摘要: Objective: One of the major causes of carcinogenesis is loss of genome stability. The double strandbreak DNA repair pathway, including X-ray repair cross complementing group 2 (XRCC2)gene, is implicated in maintenance integrity of genome and therefore could affect endometrial cancer(EC) risk. The purpose of this study was to evaluate the clinical significance of the XRCC2 4234G/C(rs3218384) gene single nucleotide polymorphism (SNP) in endometrial cancer patients. Material and Methods: The study included 1632 patients: 808 with endometrial cancer and 824healthy controls. XRCC2 4234G/C (rs3218384) polymorphism was genotyped by the PCR-RFLP(restriction fragment-length polymorphism) method. The associations of the analysed genotypes andclinical data at diagnosis have been evaluated. Results:...
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关键词翻译
关键词翻译
  • endometrial 子宫内膜的
  • Association 美国公共卫生协会
  • complementing 求反运算
  • uterine 子宫的
  • polymorphism 多晶形
  • restriction 限制
  • carcinogenesis 癌形成
  • grading 粒级成层
  • transvaginal 经阴道的
  • between 在中间