Does Dexmedetomidine Protect the Visceral Organs against the Asphxia
作者: Ayse Mizrak
刊名: International Journal of Veterinary Science and Research, 2019, Vol.5 (1), pp.001-006
来源数据库: Peertechz Publications Private Limited
DOI: 10.17352/ijvsr.000033
原始语种摘要: Background: This study was conducted to determine whether dexmedetomidine exhibits a protective effect against sudden and short term hypoxia on brain, heart, lung, liver, and kidney in rat model which sudden hyperglycemia and hypertension developed.Methods: In this randomised and double blind study, the experiment was performed on 30 male Wistar Albino rats 250-300 g weight. The rats were randomly assigned into 2 groups which are control group (C, n = 15), and dexmedetomidine group (D, n = 15). All rats were made hyperglycemic by a single injection of streptozotocin (STZ) (50 mg/kg) then, adrenalin (0.03 mg/kg) was injected intraperitonealy to make sudden hypertension. Dexmedetomidine (10 µg/kg/min, total dose 2.5-3.3 µg) was infused intraperitonealy in group D, and saline to group C....
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  • against 反对
  • streptozotocin 链脲佐菌素
  • hyperglycemia 高血糖
  • hypertension 高血压
  • incidence 入射
  • hypertensive 高血压的
  • liver 
  • glucose 葡萄糖
  • protect 庇护
  • group