ANTI-PLASMODIAL ACTIVITY OF ENGELETIN ISOLATED FROM Artocarpus scortechinii
作者: ALI, A.H HASSAN, N.M SHUKOR, N.I EMBI, N LATIP, J. & MOHD SIDEK, H.M.
刊名: Malaysian Applied Biology, 2014, Vol.43 (1)
来源数据库: Malaysian Society of Applied Biology
关键词: Anti-plasmodialArtocarpus sp.flavonoidengeletin
原始语种摘要: Ethnomedicinal use of plants from the Artocarpus genus has been extensively documented to include treatment of inflammation and malarial fever. Anti-plasmodial effects of Artocarpus scortechinii (synonym A. elasticus) reported against P. falciparum 3D7 culture in erythrocytes remain to be validated in vivo. The present study involved re-evaluation of anti-plasmodial activity of ethanolic extract of A. scortechinii in vitro, assessment of the extract for chemo-suppressive effects in vivo, and fractionation and identification of bioactive compounds. The ethanolic extract of A. scortechinii displayed moderate inhibitory activity towards growth of P. falciparum 3D7 (IC50=14.4±8.1 ug/mL) with minimal toxicity effect in mammalian Chang liver cells (selectivity index, SI=13.9). Administration of...
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关键词翻译
关键词翻译
  • 分级 活度
  • plasmodial 合胞体的
  • activity 活度
  • fractionation 活度
  • extract 提取
  • chemo 表示化学的
  • parasite 寄生物
  • selectivity 选择性
  • spectroscopy 分光学
  • moderate 适当的
  • resonance 共振