Spectrophotometric determination of paracetamol in drug formulations with 1 – naphthol
作者: Raymond T. IorhemenAondona M. IorhembaRoyalty E. SamboWinifred U. Nande
作者单位: 1Ahmadu Bello University, Zaria. iorhemenraymond@gmail.com
刊名: International Journal of Advanced Chemistry, 2017, Vol.5 (2), pp.86-90
来源数据库: Science Publishing Corporation
DOI: 10.14419/ijac.v5i2.8313
关键词: Determination of ParacetamolDrug FormulationsParacetamolParacetamol with 1-NaphtholSpectrophotometry.
原始语种摘要: Paracetamol with 1-Naphthol gave an azodye and the concentration of paracetamol was investigated spectrophotometrically. The dye formed with 1-Naphthol as a coupling agent followed Beer Lambert’s law within the range of 2 – 10 μgmL-1 of paracetamol at a lambda max (λmax) of 505nm. The molar absorptively of the azodye coupled with 1-Naphthol was found to be 1.6973×104 dm3mol-1cm-1, r2 was 0.9974. P value was found to be 0.013 at 95% confidence. LOD was 0. 02 μgmL-1 while LOQ was 0. 10 μgmL-1. The coupling agent has been applied successfully for the analysis of paracetamol in pharmaceutical preparations such as boska, ibex, mixagrip, norgesis and procold with the recovery of 101.27 %, 98.98 %, 99.47 %, 98.28 % and 101.6 % respectively. The relative standard deviation of all the five samples...
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  • paracetamol 4乙酰氨基酚
  • naphthol 萘酚
  • determination 测定
  • azodye 偶氮染料
  • pharmaceutical 
  • range 射程
  • successfully 成功地
  • applied 应用的
  • clinical 临床的
  • standard 标准