Development and evaluation of time controlled release tablet of ketoprofen for the treatment of rheumatoid arthritis
作者: P H Sharma J. G. Avari
刊名: Journal of Applied pharmaceutical Research, 2017, Vol.5 (3)
来源数据库: Creative Pharma Assent
DOI: 10.18231/2348-0335.2017.0002
关键词: Time controlled drug deliveryKetoprofenCrosscarmellose sodiumEthylcelluloseRheumatoid arthritis
原始语种摘要: The aim of present study was to develop and evaluate time controlled release tablet of Ketoprofen intended for rheumatoid arthritis. The cardinal sign of rheumatoid arthritis are stiffness, swelling and pain of one or more joints of the body characteristically most severe in the morning. Rheumatoid arthritis shows a significant circadian variation in its symptoms. Time controlled release tablet delivers the drug at definite time or in controlled rate. It consist of core tablet coated with two layers, the inner swelling layer and outer rupturable. Before compression of core tablet, drug- excipients compatibility study and precompression parameters were investigated. Core tablet was prepared by direct compression method. After evaluating core tablet for different evaluation parameter of...
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  • tablet 药片
  • controlled 受控
  • compression 压缩
  • arthritis 关节炎
  • rheumatoid 患风湿病的
  • core 岩心
  • ethylcellulose 乙基纤维素
  • ketoprofen 酮洛芬
  • layer 
  • parameters 参数