Thermoresponsive, redox-polymerized cellulosic hydrogels undergo in situ gelation and restore intervertebral disc biomechanics post discectomy
作者: D M VarmaH A LinR G LongG T GoldA C HechtJ C IatridisS B Nicoll
作者单位: 1Department of Biomedical Engineering, The City College of New York, Steinman Hall, Room 401, 160 Convent Avenue, New York, NY 10031,
刊名: Eur Cell Mater, 2018, Vol.35 , pp.300-317
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v035a21
原始语种摘要: Back and neck pain are commonly associated with intervertebral disc (IVD) degeneration. Structural augmentation of diseased nucleus pulposus (NP) tissue with biomaterials could restore degeneration-related IVD height loss and degraded biomechanical behaviors; however, effective NP replacement biomaterials are not commercially available. This study developed a novel, crosslinked, dual-polymer network (DPN) hydrogel comprised of methacrylated carboxymethylcellulose (CMC) and methylcellulose (MC), and used in vitro, in situ and in vivo testing to assess its efficacy as an injectable, in situ gelling, biocompatible material that matches native NP properties and restores IVD biomechanical behaviors. Thermogelling MC was required to enable consistent and timely gelation of CMC in situ within...
全文获取路径: European Cells and Materials (eCM)  (合作)
影响因子:4.558 (2012)

  • intervertebral 椎间的
  • hydrogel 水凝胶
  • biocompatible 生物相容的
  • injectable 可注射的
  • biomaterial 生物材料
  • restore 回复
  • biomechanics 生物力学
  • whole 全部的
  • gelation 软胶化
  • crosslinked 交联的