Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes
作者: M M GaoQ N SuT Z LiangJ X MaT Z LiangM J StoddartR G RichardsZ Y ZhouN X Zou
作者单位: 1Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology/Orthopaedic Research Institute, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong,
刊名: Eur Cell Mater, 2018, Vol.36 , pp.1-14
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v036a01
原始语种摘要: Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the main source of extracellular pyrophosphate. Along with tissue-nonspecific alkaline phosphatase (TNAP), ENPP1 plays an important role in balancing bone mineralisation. Although well established in pre-osteoblasts, the regulating mechanisms of ENPP1 in osteoblasts and osteocytes remain largely unknown. Using bioinformatic methods, osterix (Osx), an essential transcription factor in osteoblast differentiation and osteocyte function, was found to have five predicted binding sites on the ENPP1 promoter. ENPP1 and Osx showed a similar expression profile both in vitro and in vivo. Over-expression of Osx in MC3T3-E1 and MLO-Y4 cells significantly up-regulated the expression of ENPP1 (p < 0.05). The consensus Sp1 sequences, located...
全文获取路径: European Cells and Materials (eCM)  (合作)
影响因子:4.558 (2012)

  • expression 表示
  • promoter 催化剂
  • pyrophosphate 焦磷酸盐
  • chromatin 染色质
  • demonstrated 探明的储量
  • together 共同
  • consensus 合意
  • confirmed 已确认的
  • transcription 地名转写
  • regulating 蝶的