Improved tendon healing using bFGF, BMP-12 and TGFβ1 in a rat model
作者: M MajewskiP HeisterbachC JaquiéryL DürselenA TodoroI MartinC H EvansS A Müller
作者单位: 1Department of Orthopaedic Surgery, University of Basel, Spitalstrasse 21, 4031 Basel,
刊名: Eur Cell Mater, 2018, Vol.35 , pp.318-334
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v035a22
原始语种摘要: Several growth factors (GFs) are expressed as tendons heal, but it remains unknown whether their combined application enhances the healing process. This matter was addressed by applying a combination of basic fibroblast growth factor (bFGF), bone morphogenetic protein 12 (BMP-12) and transforming growth factor beta 1 (TGFβ1) in a rat Achilles tendon transection model. GFs were applied in one of the three following ways: i) direct application of all three factors at the time of surgery; ii) sequential, tiered percutaneous injection of individual factors immediately after surgery, 48 h and 96 h later; iii) load of all three factors onto a collagen sponge implanted at the time of surgery. After 1, 2, 4 and 8 weeks, healing was assessed based on tendon length and thickness, mechanical...
全文获取路径: European Cells and Materials (eCM) 
影响因子:4.558 (2012)

  • 收信地址 特别地
  • tendon 钢筋束
  • three 
  • mechanical 机械的
  • especially 特别地
  • addressed 特别地
  • healing 加硫
  • sponge 海绵硬朊
  • applying 施加
  • faster 加快
  • option 选择