Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity
作者: A SadowskaT KamedaO KrupkovaK Wuertz-Kozak
作者单位: 1Institute for Biomechanics, D-HEST, ETH Zurich, Hönggerbergring 64, HPP-O12, 8093 Zurich, Switzerland.kwuertz@ethz.ch
刊名: Eur Cell Mater, 2018, Vol.36 , pp.231-250
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v036a17
原始语种摘要: Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier...
全文获取路径: European Cells and Materials (eCM)  (合作)
影响因子:4.558 (2012)

  • osmotic 渗透的
  • osmolarity 克分子渗透压浓度
  • cells 麻风细胞
  • inflammation 炎症
  • stress 应力
  • intervertebral 椎间的
  • potential 
  • factor 因素
  • respond 应答
  • degradation 减嚣夷酌