Engineering of a complex bone tissue model with endothelialised channels and capillary-like networks
作者: B J KlotzK S LimY X ChangB J SolimanI PenningsF P MelchelsF P MelchelsA J RosenbergJ MaldaD Gawlittal
作者单位: 1UMC Utrecht, Heidelberglaan 100, PO Box 85500, 3508GA Utrecht, the Netherlands.D.Gawlitta@umcutrecht.nl
刊名: Eur Cell Mater, 2018, Vol.35 , pp.335-348
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v035a23
原始语种摘要: In engineering of tissue analogues, upscaling to clinically-relevant sized constructs remains a significant challenge. The successful integration of a vascular network throughout the engineered tissue is anticipated to overcome the lack of nutrient and oxygen supply to residing cells. This work aimed at developing a multiscale bone-tissue-specific vascularisation strategy.Engineering pre-vascularised bone leads to biological and fabrication dilemmas. To fabricate channels endowed with an endothelium and suitable for osteogenesis, rather stiff materials are preferable, while capillarisation requires soft matrices. To overcome this challenge, gelatine-methacryloyl hydrogels were tailored by changing the degree of functionalisation to allow for cell spreading within the hydrogel, while still...
全文获取路径: European Cells and Materials (eCM)  (合作)
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影响因子:4.558 (2012)

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关键词翻译
关键词翻译
  • hydrogel 水凝胶
  • capillary 毛状的
  • constructs 建筑图纸生成系统
  • biomaterial 生物材料
  • osteogenic 成骨的
  • challenge 询问
  • complex 超群
  • cells 麻风细胞
  • osteogenesis 骨生成
  • gelatine