Towards an intraoperative engineering of osteogenic and vasculogenic grafts from the stromal vascular fraction of human adipose tissue
作者: A M MüllerA MehrkensD J SchäferC JaquieryS GüvenM LehmickeR MartinettiI FarhadiM JakobA ScherberichI Martin
作者单位: 1Institute for Surgical Research and Hospital Management, University Hospital Basel, Hebelstrasse 20, CH‐4031 Basel, Switzerland.imartin@uhbs.ch
刊名: Eur Cell Mater, 2010, Vol.19 , pp.127-135
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v019a13
原始语种摘要: Grafts generated by cultivation of progenitor cells from the stromal vascular fraction of human adipose tissue have been proven to have osteogenic and vasculogenic properties in vivo. However, in vitro manufacture of such implants is challenged by complex, impractical and expensive processes, and requires implantation in a separate surgery. This study investigates the feasibility of an intraoperative approach to engineer cell‐based bone grafts with tissue harvest, cell isolation, cell seeding onto a scaffold and subsequent implantation within a few hours. Freshly isolated adipose tissue cells from a total of 11 donors, containing variable fractions of mesenchymal and endothelial progenitors, were embedded at different densities in a fibrin hydrogel, which was wrapped around bone...
全文获取路径: European Cells and Materials (eCM)  (合作)
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影响因子:4.558 (2012)

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关键词翻译
关键词翻译
  • osteogenic 成骨的
  • adipose 脂肪的
  • vascular 维管的
  • hyphen 连字符
  • stromal 基质的
  • tissue 组织
  • tricalcium 三钙
  • mesenchymal 间叶细胞的
  • hydrogel 水凝胶
  • constructs 建筑图纸生成系统