Effective repair of articular cartilage using human pluripotent stem cell-derived tissue
作者: O F GardnerS C JunejaH WhetstoneY NartissJ T SiekerC VeilletteG M KellerA M Craft
作者单位: 1Department of Orthopedic Surgery, Boston Children’s Hospital, Enders 260, Mailstop 3096, 300 Longwood Avenue, Boston, MA 02115, USA. april.craft@childrens.harvard.edu
刊名: Eur Cell Mater, 2019, Vol.38 , pp.215-227
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v038a15
原始语种摘要: In an effort to develop an effective source of clinically relevant cells and tissues for cartilage repair a directed differentiation method was used to generate articular chondrocytes and cartilage tissues from human embryonic stem cells (hESCs). It has previously been demonstrated that chondrocytes derived from hESCs retain a stable cartilage-forming phenotype following subcutaneous implantation in mice. In this report, the potential of hESC-derived articular-like cartilage to repair osteochondral defects created in the rat trochlea was evaluated. Articular cartilage-like tissues were generated from hESCs and implanted into the defects. After 6 and 12 weeks, the defects were evaluated histologically and immunohistochemically, and the quality of repair was assessed using a modified ICRS...
全文获取路径: European Cells and Materials (eCM) 
影响因子:4.558 (2012)

  • articular 关节的
  • cartilage 软骨
  • repair 修理
  • pluripotent 多能的
  • derived 导生的
  • implant 离子注入
  • ossification 骨化
  • human 人的
  • trochlea 滑车
  • subchondral 软骨下的