Modulation of macrophage phenotype through controlled release of interleukin-4 from gelatine coatings on titanium surfaces
作者: C L YangY H SunW H YuX Z YinJ WengB Feng
作者单位: 1Key Laboratory of Advanced Technology for Materials (Ministry of Education), School of Materials Science and Engineering, University of the Southwest Jiaotong University, Jinniu District, Chengdu,
刊名: Eur Cell Mater, 2018, Vol.36 , pp.15-29
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v036a02
原始语种摘要: Pro-inflammatory phenotype (M1) macrophages initiate angiogenesis, while their prolonged activation can induce chronic inflammation. Anti-inflammatory phenotype (M2) macrophages promote vessel maturation and tissue regeneration. Biomaterials which can promote M2 polarisation after appropriate inflammation should enhance angiogenesis and wound healing. Herein, Interleukin-4 (IL-4), an anti-inflammatory cytokine, was adsorbed onto a titanium surface. Then, a genipin cross-linked gelatine hydrogel was coated onto the surface to delay IL-4 release. The cross-linking degree of the hydrogel was modulated by the different amount of genipin to control release of IL-4. When 0.7 wt% (weight %) genipin was used as a cross-linker, the sample (GG07-I) released less IL-4 within the first several days,...
全文获取路径: European Cells and Materials (eCM)  (合作)
影响因子:4.558 (2012)

  • interleukin 白细胞间介素
  • macrophage 巨噬细胞
  • phenotype 表型
  • gelatine 
  • release 释放
  • hydrogel 水凝胶
  • cytokines 细胞浆移动
  • inflammation 炎症
  • biomaterial 生物材料
  • secretion 分泌