Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts
作者: F Shapiro
作者单位: 1Department of Orthopaedic Surgery, Orthopaedic Research Laboratories, Children's Hospital Boston, Boston MA,
刊名: Eur Cell Mater, 2008, Vol.15 , pp.53-76
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v015a05
原始语种摘要: Bone development occurs by two mechanisms: intramembranous bone formation and endochondral bone formation. Bone tissue forms by eventual differentiation of osteoprogenitor cells into either mesenchymal osteoblasts (MOBL), which synthesize woven bone in random orientation, or surface osteoblasts (SOBL), which synthesize bone on surfaces in a well oriented lamellar array. Bone repair uses the same formation patterns as bone development but the specific mechanism of repair is determined by the biomechanical environment provided. Bone synthesis and maintenance are highly dependent on the blood supply of bone and on cell‐cell communication via the lacunar‐canalicular system. Recent investigations highlight the molecular cascades leading to cell...
全文获取路径: European Cells and Materials (eCM) 
影响因子:4.558 (2012)

  • woven 编织
  • surface 
  • lamellar 层纹状的
  • development 开发
  • formation 建造
  • synthesize 合成
  • repair 修理
  • mesenchymal 间叶细胞的
  • orientation 定向
  • eventual 可能发生的