Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages
作者: J XuA NygaW LiX ZhangN GavaraM M KnightJ C Shelton
作者单位: 1Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, UK.j.shelton@qmul.ac.uk
刊名: Eur Cell Mater, 2018, Vol.36 , pp.142-155
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v036a11
原始语种摘要: Many studies report the adverse responses to metal-on-metal (MoM) hip prostheses, with tissues surrounding failed MoM hip prostheses revealing abundant tissue necrosis and fibrosis. These local effects appear to be initiated by metal ions released from the prosthesis causing the secretion of inflammatory mediators. However, little is known about the effect of the metal ions on tissue remodelling and pseudotumor formation, which are also associated with the failure of MoM hip prostheses. The peri-prosthetic soft tissue masses can lead to pain, swelling, limited range of joint movement and extensive tissue lesion. To elucidate this cellular response, a multidisciplinary approach using both two- and three-dimensional (2D and 3D) in vitro culture systems was employed to study the effects of...
全文获取路径: European Cells and Materials (eCM)  (合作)
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来源刊物:
影响因子:4.558 (2012)

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关键词翻译
关键词翻译
  • fibrotic 纤维变性的
  • fibroblast 成纤维细胞
  • remodelling 重装
  • response 响应
  • matrix 石基
  • triggered 触发的
  • abundant 丰富的
  • extensive 广泛的
  • increased 增加
  • tissue 组织