Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker
作者: A J TurloA J Mueller-BreckenridgeD E ZamboulisS R TewE G Canty-LairdP D Clegg
作者单位: 1Institute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, L7 8TX Liverpool, UK.a.turlo@liverpool.ac.uk
刊名: Eur Cell Mater, 2019, Vol.38 , pp.123-136
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v038a10
原始语种摘要: The main challenge in tendon injury management is suboptimal tissue healing that fails to re-establish original tendon function. Tissue bioengineering is a promising approach for tendon therapy, with potential to improve its functional outcomes. However, evaluation criteria for tissue-engineered tendon are unclear due to the lack of specific markers of differentiated tendon. The study aim was to identify a panel of genes that characterised tendons in comparison to cartilage or muscles and validate those genes, both in human and key species used as models for tendon diseases. Gene expression profiling of rat tendon and cartilage in whole-tissue samples and primary tenocytes and chondrocytes was undertaken using two independent microarray platforms. Genes that demonstrated high expression...
全文获取路径: European Cells and Materials (eCM)  (合作)
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来源刊物:
影响因子:4.558 (2012)

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关键词翻译
关键词翻译
  • tendon 钢筋束
  • protein 蛋白质
  • marker 标试器
  • species 
  • factor 因素
  • growth 生长
  • cartilage 软骨
  • permissive 许可的
  • expression 表示
  • muscles 筋肉