Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics
作者: R HartmanP PatilR TishermanC St. CroixL J NiedernhoferP D RobbinsF AmbrosioB Van HoutenG SowaN Vo
作者单位: 1Ferguson Laboratory for Orthopaedic Research, 200 Lothrop St., E1648 University of Pittsburgh, Pittsburgh, PA 15213,
刊名: Eur Cell Mater, 2018, Vol.36 , pp.171-183
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v036a13
原始语种摘要: Robust cellular bioenergetics is vital in the energy-demanding process of maintaining matrix homeostasis in the intervertebral disc. Age-related decline in disc cellular bioenergetics is hypothesised to contribute to the matrix homeostatic perturbation observed in intervertebral disc degeneration. The present study aimed to measure how ageing impacted disc cell mitochondria and bioenergetics. Age-related changes measured included matrix content and cellularity in disc tissue, as well as matrix synthesis, cell proliferation and senescence markers in cell cultures derived from annulus fibrosus (AF) and nucleus pulposus (NP) isolated from the discs of young (6-9 months) and older (36-50 months) New Zealand White rabbits. Cellular bioenergetic parameters were measured using a Seahorse XFe96...
全文获取路径: European Cells and Materials (eCM) 
影响因子:4.558 (2012)

  • mitochondria 线粒体
  • bioenergetics 生物能学
  • intervertebral 椎间的
  • contribute 贡献
  • cells 麻风细胞
  • matrix 石基
  • potential 
  • reduced 减缩的
  • respiration 呼吸
  • degenerative 退化的