Dexamethasone: chondroprotective corticosteroid or catabolic killer?
作者: R BlackA J Grodzinsky
作者单位: 1MIT, Centre for Biomedical Engineering, 500 Technology Square, Cambridge, MA, 02139,
刊名: Eur Cell Mater, 2019, Vol.38 , pp.246-263
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v038a17
原始语种摘要: While glucocorticoids have been used for over 50 years to treat rheumatoid and osteoarthritis pain, the prescription of glucocorticoids remains controversial because of potentially harmful side effects at the molecular, cellular and tissue levels. One member of the glucocorticoid family, dexamethasone (DEX) has recently been demonstrated to rescue cartilage matrix loss and chondrocyte viability in animal studies and cartilage explant models of tissue injury and post-traumatic osteoarthritis, suggesting the possibility of DEX as a disease-modifying drug if used appropriately. However, the literature on the effects of DEX on cartilage reveals conflicting results on the drug’s safety, depending on the dose and duration of DEX exposure as well as the model system used. Overall, DEX has been...
全文获取路径: European Cells and Materials (eCM)  (合作)
影响因子:4.558 (2012)

  • Dexamethasone 地塞米松
  • corticosteroid 皮质甾类
  • osteoarthritis 骨关节炎
  • glucocorticoid 糖皮质激素
  • chondrocyte 软骨细胞
  • inflammation 炎症
  • rheumatoid 患风湿病的
  • potentially 可能地
  • cartilage 软骨
  • dexamethasone 地塞米松