Preclinical in vivo models of fracture-related infection: a systematic review and critical appraisal
作者: N VanvelkM MorgensternT F MoriartyR G RichardsS NijsW J Metsemakers
作者单位: 1Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium.willem-jan.metsemakers@uzleuven.be
刊名: Eur Cell Mater, 2018, Vol.36 , pp.184-199
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v036a14
原始语种摘要: A fracture-related infection (FRI) is an important complication that can lead to an increase in morbidity, mortality and economic costs. Preclinical in vivo models are critical in the evaluation of novel prevention and treatment strategies, yet it is important that these studies recapitulate the features of an FRI that make it such a clinical challenge. The aim of this systematic review was to survey the available preclinical models of FRIs and assess which of the key FRI-specific parameters are incorporated in these models.A comprehensive search was performed on July 1st 2017 in PubMed, Embase and Web of Science. Overall, 75 preclinical studies were identified, 97.3 % (n = 73) of which use Staphylococcus aureus as the causative microorganism. The most common mode for creation of bone...
全文获取路径: European Cells and Materials (eCM)  (合作)
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影响因子:4.558 (2012)

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关键词翻译
关键词翻译
  • review 复审
  • appraisal 估价
  • FRI 星期五
  • systematic 有系统的
  • fracture 断口
  • incorporate 加入
  • creation 创造
  • critical 临界的
  • economic 经济的
  • costs 费用