Mesenchymal stem cell secretome reduces pain and prevents cartilage damage in a murine osteoarthritis model
作者: S KhatabG J van OschN KopsY M Bastiaansen-JenniskensP K BosJ A VerhaarM R BernsenG M van Buul
作者单位: 1epartment of Orthopaedics and Otorhinolaryngology, Erasmus MC, University Medical Centre, Wytemaweg 80, 3015 CN Rotterdam, the Netherlands.g.vanosch@erasmusmc.nl
刊名: Eur Cell Mater, 2018, Vol.36 , pp.218-230
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v036a16
原始语种摘要: Mesenchymal stem cells (MSCs) represent a promising biological therapeutic option as an osteoarthritis (OA)-modifying treatment. MSCs secrete factors that can counteract inflammatory and catabolic processes and attract endogenous repair cells. The effects of intra-articular injection of MSC secretome on OA-related pain, cartilage damage, subchondral bone alterations and synovial inflammation were studied in a mouse collagenase-induced OA model. The MSC secretome was generated by stimulating human bone-marrow-derived MSCs with interferon gamma (IFNγ) and tumour necrosis factor alpha (TNFα). 54 mice were randomly assigned to injections with i) MSC secretome from 20,000 MSCs, ii) 20,000 MSCs or iii) medium (control). Pain was assessed by hind limb weight distribution. Cartilage damage,...
全文获取路径: European Cells and Materials (eCM)  (合作)
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影响因子:4.558 (2012)

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关键词翻译
关键词翻译
  • murine 鼠灰色
  • osteoarthritis 骨关节炎
  • inflammation 炎症
  • damage 损伤
  • synovial 关节的
  • subchondral 软骨下的
  • injections 用政府支出来刺激需求增长
  • cartilage 软骨
  • gamma 伽马
  • macrophage 巨噬细胞