Synthesis and Antimicrobial Evaluation of Novel 4-Methyl-7-((5-Aryl-4H-1,2,4-Triazol-3-Yl)Methoxy)-2H-Benzopyran-2-Ones
作者: Chand MKaushik RRashid MJain SC
作者单位: 1Department of Chemistry, University of Delhi, Delhi-110007 , India
刊名: Der Pharma Chemica, 2018, Vol.10 (8), pp.150-156
来源数据库: Scholars Research Library
关键词: 7-Hydroxy-4-methyl-2H-benzopyran-2-one124-TriazoleAntibacterialAntifungalCup-plate method
原始语种摘要: A new series of 4-methyl-7-triazolylmethoxy-2H-benzopyran-2-ones were synthesized using 7-hydroxy-4-methyl-2H-benzopyran-2-one as the starting material. It was first converted into 7-yloxyacetohydrazide by functional group inter conversion strategies and then reacted with aromatic or heterocyclic aldehydes and ammonium acetate in acetic acid to give the titled compounds. All the synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against seven strains of bacteria and four strains of fungi. MIC results of most of the synthesized compounds (14-23, 26-27 and 29) have shown them to possess promising to comparable activities while compounds 15, 19, 21, 26, 27 and 29 were found to be better antifungal agents than the standard drugs in vitro and can...
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  • heterocyclic 杂环的
  • methyl 甲基
  • aldehydes 
  • compounds 化合物
  • antibacterial 抗细菌的
  • benzopyran 苯并吡喃
  • converted 转[变]换
  • comparable 可比较的
  • ammonium 
  • aromatic 香的