Synthesis and Anti-Inflammatory Activity of New Substituted 4,5- Dihydro-3-(Naphthalene-6-Yl)-5-Phenyl Pyrazole Carbothio Aminde Derivatives
作者: Poonam KPriya MAnshuman SBhumika YSujeet KG
作者单位: 1Department of Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical Education and Research, Lucknow-226021 , India
刊名: Der Pharma Chemica, 2018, Vol.10 (8), pp.146-149
来源数据库: Scholars Research Library
关键词: PyrazoleAnti-inflammatoryChalconeCarrageenan induced rat paw edema model
原始语种摘要: In the present study we have made an attempt to synthesize substituted 4,5-dihydro-3-(naphthalene-6-yl)-5-phenyl pyrazole carbothioamide derivatives (2a-i) and evaluate them for anti-inflammatory activity using carrageenan induced rat paw edema model. In the first step, 2-acetylnaphthalene (1) was allowed to react with substituted benzaldehyde (2) in equimolar amount with sodium hydroxide to form various substituted derivatives (1a-i). Further substituted chalcone derivatives on treatment with thiosemicarbazide in the presence of ethanol corresponding substituted 4,5-dihydro-3-(naphthalene-6-yl)-5-phenyl pyrazole carbothioamide (2a-i). The structure of the final analogues has been confirmed on the basis of elemental analysis, Fourier Transform Infrared (FTIR), Proton Nuclear Magnetic...
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  • substituted 取代的
  • elemental 元素的
  • phenyl 苯基
  • pyrazole 吡唑
  • derivatives 派生物
  • synthesize 合成
  • inflammatory 激怒的
  • equimolar 等克分子的
  • FTIR Flight Test Instrumentation Requirements
  • benzaldehyde 苯醛