Design, Synthesis and Molecular Modeling of New 1,3,5-Triazine Derivatives as Anticancer Agents
作者: Marwa I. SeragRania M. GomaaMohammed A.M. MassoudHassan M. Eisa
刊名: DER PHARMA CHEMICA, 2019, Vol.11 (5)
来源数据库: Scholars Research Library
关键词: Anticancer activityCyanuric chloride135-triazinePI3KMolecular docking
原始语种摘要: A new series of 1,3,5-triazine analogues were designed, synthesized and in vitro screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines. Compound 6 the most active member in this study, showing effectiveness toward numerous cell lines belonging to different tumor cell lines that reach to 60.13% inhibition in renal cancer (CAKI-1) cell line, also it has good inhibitory activity against PI3Kγ (IC50=6.90 μM) closer activity to reference wortmannin (IC50=3.19 μM). Molecular docking reveal that compound 6 occupied the same pocket of the active site of PI3Kγ and these, consistent with biological results.
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  • lines 线型
  • triazine 三嗪
  • screened 筛过的
  • docking 靠泊
  • activity 活度
  • different 不相同的
  • consistent 可相容的
  • inhibitory 禁止的
  • chloride 氯化物
  • designed 设计了的计划了的