Reactions of Triacetonamine Part II, Synthesis of Novel Pyrazolo(4,3-c)pyridine Derivatives, and 2-(Piperidin-4-ylidene)hydrazinecarbothioamide Derivatives Derived From 2,2,6,6-Tetramethyl-piperidin-4-one for In vitro Anticancer Evaluation
作者: Mahmoud NM YousifAhmed A FayedNabil M Yousif
作者单位: 1Department of Photochemistry, Chemical Industries Research Division, National Research Centre, Dokki, 12622, Giza , Egypt
2Department of Respiratory Therapy, Faculty of Medical Rehabilitation Sciences, Taibah University, Madinah Munawara, 22624 , Saudi Arabia
刊名: Der Pharma Chemica, 2018, Vol.10 (8), pp.105-109
来源数据库: Scholars Research Library
关键词: 2266-Tetramethylpiperidin-4-onePyrazolo(43-c)pyridines5-pyrazolo[43-c]pyridin-2-yl)thiazolesAnticancer evaluation
原始语种摘要: 2,2,6,6-Tetramethylpiperidin-4-one reacts with 2 moles of aromatic aldehydes and thiosemicarbazide or semicarbazide hydrochloride in different conditions to afford piperidine derivatives 1a-f and pyrazolo(4,3-c)pyridine derivatives 2a-f. Pyrazolo[4,3-c]pyridine-2-carbothioamide derivative 2b reacts with benzophenone, 4-cholorobenzophenone, and 4-bromobenzophenone to give 5-(pyrazolo[4,3-c]pyridine-2-yl) thiazole derivatives 3a-c. Piperidine derivative 1b reacts with acetic anhydride to afford compounds 4a-b. Pyrazolo(4,3-c)pyridine derivative 2c reacts with acetic anhydride to afford compounds 5a-b. Hydrazinecarbothioamide derivative 1a reacts with benzoin and benzoin oxime to give compounds 6, and 7 respectively. Anticancer evaluation of some of synthesized compounds is reported.
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  • pyridine 吡啶
  • ylidene 
  • afford 提供
  • derivative 衍生物
  • anhydride 无水物
  • aldehydes 
  • compounds 化合物
  • piperidine 氮己烷
  • acetic 醋酸的
  • oxime