Synthesis and Biological Evaluation of N,N’-Bis(1-(2-Hydroxyphenyl)Ethylidene)-2-Methylmalonohydrazide Schiff’s Base and its Metal Complexes of First Transition Series
作者: Saini SPal RGupta AKBeniwal V
作者单位: 1Department of Chemistry, Maharishi Markandeshwar (Deemed To Be University), Mullana (Ambala) , India
2Department of Biotechnology, Maharishi Markandeshwar (Deemed To Be University), Mullana (Ambala) , India
刊名: Der Pharma Chemica, 2018, Vol.10 (8), pp.139-145
来源数据库: Scholars Research Library
关键词: 2-methylmalonohydrazide1-(2-Hydroxyphenyl)ethanoneSchiff’s baseMetal complexesAntibacterial activityDNA photocleavage
原始语种摘要: In search of new chemical nucleases the synthesis of methylmalonohydrazide based hydrazone Schiff base and its colored complexes with transition metal Co(II), Ni(II), Cu(II), Mn(II), and Zn(II) have been synthesized. All synthesized compounds were screened for antibacterial activity against gram (+) and gram (-) bacteria using Oxacillin and Penicillin-G as a reference standard and their DNA photocleavage potential were carried out by using the plasmid DNA via gel electrophoresis method. From experimental results it has been observed that biological activity increases significantly upon coordination. The synthesis of hydrazone Schiff’s base, N,N’-bis(1-(2-Hydroxyphenyl)ethylidene)-2-methylmalonohydrazide (MAPLH2) have been achieved by a condensation reaction between 2-methylmalonohydrzide...
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  • hydrazone 
  • reaction 反酌
  • coordination 配位
  • complexes 联合企业
  • transition 转移
  • elemental 元素的
  • spectroscopic 光谱的
  • antibacterial 抗细菌的
  • stoichiometric 化学计量的
  • activity 活度