UPLC Method for the Quantification of Elvitegravir, Cobicistat, Emtricitabine and Tenofovir Disoproxil Fumarate in Tablets Using OGD Reference Dissolution Medium
作者: Vittal SPRao SMRamakrishna K
作者单位: 1APL Research Centre (A Division of Aurobindo Pharma Limited), Hyderabad-500072, Telangana , India
刊名: Der Pharma Chemica, 2019, Vol.11 (3), pp.57-68
来源数据库: Scholars Research Library
关键词: ElvitegravirCobicistatEmtricitabineTenofovir DisoproxilfumarateDissolutionRP-UPLC
原始语种摘要: The current paper discuss about strategic development and validation activity performed for quantification of Elvitegravir (EL), Cobicistat (CO), Emtricitabine (EM) and Tenofovir Disoproxil fumarate (TDF) in a combination drug product using Office of Generic drugs (OGD) recommended Dissolution medium. Ultra Performance Liquid Chromatographic (UPLC) technique method was chosen and developed a method with a run time of four minutes. Mobile phase A consists of 0.1% perchloric acid and Mobile phase B consists of Acetonitrile. Gradient elution technique was opted with an optimized flow rate of 0.3 ml per minutes. Acquity UPLC BEHC18 (100 mm × 2.1 mm ID), 1.7 particle size column is finalized for testing purpose with a detection wavelength of 260 nm. Typical retention times observed...
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关键词翻译
关键词翻译
  • development 开发
  • drugs 药品
  • purpose 目的
  • proposed 建议的
  • discuss 议论
  • control 控制
  • quality 品质
  • more 更多
  • developed 开发
  • specified 给定的