Skin lesion imaging with line-field confocal optical coherence tomography
作者: Maxime CazalasOlivier LevecqHicham AzimaniDavid SiretAnaïs BarutMarianno SuppaVéronique del MarmolJosep MalvehyElisa CinottiPietro RubegniJean Luc PerrotArnaud Dubois
作者单位: DAMAE Medical (France);;Univ. Libre de Bruxelles (Belgium);;Univ. Hospital Clinic of Barcelona (Spain);;Univ. of Siena (Italy);;Univ. of Siena (Italy);;Univ. Hospital of Saint-Etienne (France);;Lab. Charles Fabry, Institut d'Optique Graduate School, Univ. Paris-Saclay (France);;Beckman Laser Institute and Medical Clinic (United States);;The BC Cancer Agency Research Ctr. (Canada)
论文集英文名称: BiOS
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/12.2508484
原始语种摘要: An improved optical coherence tomography (OCT) technique called line-field confocal OCT (LC-OCT) has been developed for high-resolution skin imaging. Combining the principles of time-domain OCT and confocal microscopy with line illumination and detection, LC-OCT acquires multiple A-scans in parallel with dynamic focusing. With a quasi isotropic resolution of ∼ 1 Μm, the LC-OCT images reveal a comprehensive structural mapping of skin, in vivo , at the cellular level down to a depth of ∼ 500 Μm. LC-OCT images of various skin lesions, including carcinomas and melanomas, are found to well correlate with histopathological images. LC-OCT could significantly improve clinical diagnostic accuracy, while reducing the number of biopsies of benign lesions.
全文获取路径: SPIE 

  • coherence 相干性
  • imaging 图像形成
  • tomography 断层x 线摄影
  • optical 光学的
  • illumination 光照强度
  • confocal 共焦
  • focusing 
  • technique 技术
  • microscopy 显微镜检查
  • field