Camelid variable fragments of heavy chain antibodies (Nanobody): its applications in research, diagnosis and therapy
重链抗体( Nanobody )的驼状可变片段:其在研究、诊断和治疗中的应用
作者: Hossein AghamollaeiSeyed L Mousavi GargariMohamad J RasaeeMostafa Ghanei
刊名: Minerva Biotecnologica, 2017, Vol.29 (2)
来源数据库: ProQuest Journal
原始语种摘要: Â Camelids produce functional antibodies lacking light chains with their single N-terminal domains capable of binding to antigen. The antigen-binding site of these unusual heavy chain antibodies can be easily generated as recombinant proteins in variety of hosts as single domain antibodies (sdAbs) or nanobodies. The strict monomeric behavior and small size in combination with other biochemical properties including high specificity, affinity and high solubility, make single domain antibodiesas as ideal tools which can be used in different areas. In this review we overview different properties of nanobodies, their production process and their application in biotechnology, imaging, detection,...
全文获取路径: ProQuest  (合作)
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影响因子:0.379 (2012)

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关键词翻译
关键词翻译
  • heavy 重大的
  • their 他们的
  • treatment 处理
  • easily 容易地
  • properties 道具
  • domain 领域
  • chain 
  • solubility 溶度
  • single 单独的
  • strict 精密的