Successful treatment of disseminated candidiasis resistant to amphotericin B by liposomal amphotericin B: a case report
作者: P. C. GokhaleR. J. BarapatreS. H. AdvaniN. A. KshirsagarS. K. Pandya
作者单位: 1Department of Pharmacology, Seth G.S. Medical College and K.E.M. Hospital
2Department of Medical Oncology, Tata Memorial Hospital
3Department of Neurosurgery, Seth G.S. Medical College and K.E.M. Hospital
刊名: Journal of Cancer Research and Clinical Oncology, 1993, Vol.119 (10), pp.569-571
来源数据库: Springer Journal
DOI: 10.1007/BF01372718
关键词: Acute lymphoblastic leukaemiaChronic disseminated candidiasisAmphotericin BSmall unilamellar liposomes
英文摘要: Abstract(#br)The case of a female patient with acute lymphoblastic leukaemia and chronic disseminated candidiasis, who was refractory to 1.8 g conventional amphotericin B therapy, is reported. She experienced severe amphotericin-B-related side-effects in spite of pretreatment, but was subsequently successfully treated with 3 g of a small unilamellar liposome formulation of amphotericin B prepared from soya phosphatidylcholine and cholesterol in a 7∶3 molar ratio at our institute. The patient experienced minimal side-effects with this preparation, although no pretreatment was given. Liposomal amphotericin B prepared in our institute appears to be a safe and effective therapy for systemic fungal infections. However, large controlled studies are required to determine more precisely the...
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关键词翻译
关键词翻译
  • amphotericin 两性霉素
  • candidiasis 念珠菌病
  • disseminated 浸染的
  • resistant 耐久的
  • treatment 处理