In vitro generation of effector cells cytotoxic to autologous targets from chronic myeloid leukemia patients in remission
作者: R. SomasundaramS. G. A. RaoS. H. AdvaniSudha G. Gangal
作者单位: 1Immunology Division, Cancer Research Institute, Tata Memorial Centre Parel
2Cell Biology Division, Cancer Research Institute, Tata Memorial Centre
刊名: Cancer Immunology Immunotherapy, 1988, Vol.27 (2), pp.177-182
来源数据库: Springer Journal
DOI: 10.1007/BF00200024
英文摘要: Summary(#br)Peripheral blood lymphocytes (PBL) from chronic myeloid leukemia (CML) patients in remission were stimulated in vitro, in a 3-cell assay with autologous leukemic cells or autologous bone marrow (BM) cells alone, or each in combination with allogeneic PBL. The responder cells were used as effectors in a 4-h 51 Cr release cytotoxicity assay using autologous targets such as leukemic cells, BM cells, phytohemagglutinin-induced lymphoblasts, and allogeneic K562 (erythroblastoid leukemic cell line) target cells. Sensitization of lymphocytes from CML patients with either autologous leukemic cells or BM cells generated cytotoxic cells (CTCs) capable of killing both the targets. These results suggested that in CML, the PBL may have been sensitized to myeloid maturation-related antigens...
全文获取路径: Springer  (合作)
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影响因子:3.637 (2012)

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关键词翻译
关键词翻译
  • remission 缓解
  • leukemia 白血病
  • myeloid 骨髓的
  • cytotoxic 细胞毒素的
  • generation 世代
  • effector 效应器效应物
  • cells 麻风细胞
  • chronic 延续很长的
  • autologous 自体的
  • vitro 体外