Reactive oxygen species involved in sulforaphane-induced STAT3 inactivation and apoptosis in DU145 prostate cancer cells
作者: Wonil KohKwang Seok AhnSoo-Jin JeongHyo-Jung LeeMinseok KimHyo-Jeong LeeEun-Ok LeeSung-Hoon Kim
作者单位: 1College of Oriental Medicine, Kyung Hee University
2College of Dental Medicine, Tufts University
刊名: Chinese Science Bulletin, 2010, Vol.55 (34), pp.3922-3928
来源数据库: Springer Nature Journal
DOI: 10.1007/s11434-010-4169-1
关键词: sulforaphaneSTAT3apoptosisreactive oxygen speciesDU145
英文摘要: Abstract(#br)Signal transducer and activator of transcription factor 3 (STAT3) is a transcription factor that regulates various cellular processes such as proliferation, survival and angiogenesis in cancer cells. In the present study, we investigated the mechanisms whereby isothiocyanate sulforaphane (SFN) suppresses STAT3 activation in DU145 prostate cancer cells. SFN significantly inhibited SFN-inhibited STAT3 phosphorylation at Tyr705 as well as the deoxyribonucleic acid (DNA) binding capability in electrophoresis mobility shift assay (EMSA) in time- and concentration-dependent manner. SFN also abrogated the Janus activated kinase 2 (JAK2) phosphoraylation. In addition, SFN down-regulated STAT3-related gene products including Bcl-2, Bcl-x L , and cyclin D1 and vascular endothelial...
全文获取路径: Springer Nature  (合作)
影响因子:1.319 (2012)

  • inactivation 失活
  • induced 感应的
  • prostate 前列腺
  • apoptosis 细胞死
  • cancer 癌症
  • involved 涉及
  • STAT 静止的
  • cells 麻风细胞
  • oxygen 
  • species