Influence of CYP2C9 and CYP2C19 genetic polymorphisms on phenytoin-induced neurological toxicity in Indian epileptic patients
作者: Ramasamy KesavanSunil K. NarayanChandrasekaran Adithan
作者单位: 1Department of Pharmacology, Center for Advance Research in Pharmacogenomics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
2Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
刊名: European Journal of Clinical Pharmacology, 2010, Vol.66 (7), pp.689-696
来源数据库: Springer Journal
DOI: 10.1007/s00228-010-0817-2
关键词: CYP2C9CYP2C19EpilepticsHaplotypesNeurotoxicityPhenytoin
英文摘要: Abstract(#br) Objective(#br)Cytochrome P450 2C9 and 2C19 ( CYP2C9 and CYP2C19 , respectively) genetic polymorphisms play an important role in phenytoin (PHT) metabolism. We have evaluated whether these genetic polymorphisms have an effect on PHT-induced neurological toxicity in Tamilian (ethnic group native to southern India) patients with epilepsy.(#br) Methods(#br)We studied 292 Tamilian patients who were taking PHT for the treatment of various epileptic seizures. PHT toxicity was defined on the basis of neurological signs of toxicity and further sub-classified into mild, moderate, and severe toxicity based on clinical severity. Genomic DNA was extracted from peripheral leukocytes and genotyped for CYP2C9*2 , *3 and CYP2C19*2 , *3 by PCR-restriction fragment length polymorphism...
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影响因子:2.741 (2012)

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关键词翻译
关键词翻译
  • epileptic 癫痫
  • phenytoin 苯妥英
  • induced 感应的
  • toxicity 毒性
  • genetic 遗传的
  • Indian 印弟安星座