SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer
作者: Margaret R. KaragasAngeline S. AndrewHeather H. NelsonZhongze LiTracy PunshonAlan SchnedCarmen J. MarsitJ. Steven MorrisJason H. MooreAnna L. TylerDiane Gilbert-DiamondMary-Lou GuerinotKarl T. Kelsey
作者单位: 1Section of Biostatistics and Epidemiology, Dartmouth Medical School
2Division of Epidemiology and Community Health and Masonic Cancer Center, University of Minnesota
3Biostatistics Shared Resource, Norris Cotton Cancer Center, Dartmouth Medical School
4Department of Biological Sciences, Dartmouth College
5Department of Pathology, Dartmouth Medical School
6Department of Pharmacology and Toxicology, Dartmouth Medical School
7Research Reactor Center, University of Missouri-Columbia
8Department of Genetics, Dartmouth Medical School
9Department of Pathology and Laboratory Medicine, Brown University
10Department of Community Health, Brown University
刊名: Human Genetics, 2012, Vol.131 (3), pp.453-461
来源数据库: Springer Journal
DOI: 10.1007/s00439-011-1090-x
英文摘要: Abstract(#br)Arsenic is a carcinogen that contaminates drinking water worldwide. Accumulating evidence suggests that both exposure and genetic factors may influence susceptibility to arsenic-induced malignancies. We sought to identify novel susceptibility loci for arsenic-related bladder cancer in a US population with low to moderate drinking water levels of arsenic. We first screened a subset of bladder cancer cases using a panel of approximately 10,000 non-synonymous single nucleotide polymorphisms (SNPs). Top ranking hits on the SNP array then were considered for further analysis in our population-based case–control study ( n = 832 cases and 1,191 controls). SNPs in the fibrous sheath interacting protein 1 ( FSIP1 ) gene (rs10152640) and the solute carrier family 39, member 2 ( SLC39A2...
全文获取路径: Springer  (合作)
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影响因子:4.633 (2012)

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关键词翻译
关键词翻译
  • bladder 膀胱
  • potential 
  • arsenic 
  • cancer 癌症
  • related 有关的
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