FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
作者: Stamatios TheocharisJerzy KlijanienkoConstantinos GiaginisParaskevi AlexandrouEfstratios PatsourisXavier Sastre-Garau
作者单位: 1Department of Pathology, Institut Curie
2First Department of Pathology, Medical School, University of Athens
3Department of Food Science and Nutrition, University of the Aegean
刊名: Journal of Cancer Research and Clinical Oncology, 2012, Vol.138 (8), pp.1369-1377
来源数据库: Springer Journal
DOI: 10.1007/s00432-012-1215-1
关键词: Mobile tongue squamous cell carcinomaFAKSrcClinicopathological parametersPrognosisImmunohistochemistry
英文摘要: Abstract(#br) Purpose(#br)Focal adhesion kinase (FAK) and Src are protein tyrosine kinases, localized in the focal adhesions, which, upon activation interacts each other, regulate several cellular signaling pathways implicated in malignant transformation and disease progression. The present study aimed to evaluate the clinical significance of FAK and Src protein expression in mobile tongue squamous cell carcinoma (SCC).(#br) Methods(#br)FAK and Src protein expression was assessed immunohistochemically on 48 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics, overall and disease-free patients’ survival.(#br) Results(#br)FAK positivity was noted in 32 (66.67 %) and Src positivity in 45 (93.75 %) out of 48 mobile tongue SCC cases. FAK and...
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  • squamous 具鳞的
  • survival 生存
  • carcinoma 癌症
  • tongue 岩舌
  • expression 表示
  • parameters 参数
  • mobile 可动的