Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase
作者: Kamila BorowczykJoanna TisończykHieronim Jakubowski
作者单位: 1Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ-New Jersey Medical School
2Department of Environmental Chemistry, Lodz University
3Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University
4Institute of Bioorganic Chemistry
5Department of Biochemistry and Biotechnology, University of Life Sciences
刊名: Amino Acids, 2012, Vol.43 (3), pp.1339-1348
来源数据库: Springer Nature Journal
DOI: 10.1007/s00726-011-1207-5
关键词: Bleomycin hydrolaseHomocysteine thiolactoneBrainSeizuresAlzheimer’s disease
原始语种摘要: Abstract(#br)Genetic or nutritional disorders in homocysteine (Hcy) metabolism elevate Hcy-thiolactone and cause heart and brain diseases. Hcy-thiolactone has been implicated in these diseases because it has the ability to modify protein lysine residues and generate toxic N -Hcy-proteins with auto-immunogenic, pro-thrombotic, and amyloidogenic properties. Bleomycin hydrolase (Blmh) has the ability to hydrolyze l -Hcy-thiolactone (but not d -Hcy-thiolactone) to Hcy in vitro, but whether this reflects a physiological function has been unknown. Here, we show that Blmh −/− mice excreted in urine 1.8-fold more Hcy-thiolactone than wild-type Blmh +/+ animals ( P = 0.02). Hcy-thiolactone was elevated 2.3-fold in brains ( P = 0.004) and 2.0-fold in kidneys ( P = 0.047) of Blmh −/− mice relative...
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影响因子:3.914 (2012)

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关键词翻译
关键词翻译
  • neurotoxicity 神经中毒性
  • bleomycin 博莱霉素
  • homocysteine 同型胱氨酸
  • hydrolase 水解酶
  • protective 保护的