Molecular response of Escherichia coli adhering onto nanoscale topography
作者: Loris RizzelloAntonio GaleoneGiuseppe VecchioVirgilio BrunettiStefania SabellaPier Paolo Pompa
作者单位: 1Center for Bio-Molecular Nanotechnologies, Instituto Italiano di Tecnologia@UniLe
刊名: Nanoscale Research Letters, 2012, Vol.7 (1), pp.1-8
来源数据库: Springer Journal
DOI: 10.1186/1556-276X-7-575
关键词: BacteriaNanotopographyAdhesionMolecular response
英文摘要: Abstract(#br)Bacterial adhesion onto abiotic surfaces is an important issue in biology and medicine since understanding the bases of such interaction represents a crucial aspect in the design of safe implant devices with intrinsic antibacterial characteristics. In this framework, we investigated the effects of nanostructured metal substrates on Escherichia coli adhesion and adaptation in order to understand the bio-molecular dynamics ruling the interactions at the interface. In particular, we show how highly controlled nanostructured gold substrates impact the bacterial behavior in terms of morphological changes and lead to modifications in the expression profile of several genes, which are crucially involved in the stress response and fimbrial synthesis. These results mainly demonstrate...
全文获取路径: Springer  (合作)
影响因子:2.524 (2012)

  • topography 地形学
  • Escherichia 埃希氏菌属
  • adhering 粘附性的
  • response 响应