Cellular ontogeny of RBMY during human spermatogenesis and its role in sperm motility
作者: Shadaan AbidVrushali Sagare-PatilJyotsna GokralDeepak Modi
作者单位: 1Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health
刊名: Journal of Biosciences, 2013, Vol.38 (1), pp.85-92
来源数据库: Springer Nature Journal
DOI: 10.1007/s12038-012-9281-8
关键词: HumanmotilityRBMYRNA-binding proteinspermatogenesisspermatozoatestis
英文摘要: Abstract(#br)The Y-chromosome-encoded gene RBMY (RNA-binding motif on Y) is a male germline RNA-binding protein and is postulated to be a RNA-splicing regulator. In order to understand the roles of RBMY in different stages of male gamete maturation, the present study aimed at determining its cellular expression during spermatogenesis, spermeogenesis and in mature spermatozoa. In the spermatogonia (cKIT-positive cells), RBMY immunolocalized as two distinct foci, one in the nucleolus and the other in the subnuclear region; in the spermatocytes (cKIT-negative cells), the nucleus had punctuate staining with a subnuclear foci; in the pachytene cells, the protein was localized as a punctuate pattern in the nucleus spread along the elongating chromosomes. In the round and the elongating...
全文获取路径: Springer Nature  (合作)
影响因子:1.759 (2012)

  • sperm 精子
  • ontogeny 个体发生学
  • motility 游动性
  • human 人的
  • during 在的期间