Hes1 is required for the development of pharyngeal organs and survival of neural crest-derived mesenchymal cells in pharyngeal arches
作者: Yoko KamedaTakayoshi SaitohNoriko NemotoTokio KatohSachiko IsekiTakao Fujimura
作者单位: 1Department of Anatomy, Kitasato University School of Medicine
2Graduate school of Science, Kitasato University
3Research Center for Biological Imaging, Kitasato University School of Medicine
4Molecular Craniofacial Embryology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
5Department of Dermatology, Kitasato University School of Medicine
刊名: Cell and Tissue Research, 2013, Vol.353 (1), pp.9-25
来源数据库: Springer Journal
DOI: 10.1007/s00441-013-1649-z
关键词: Neural crest cellsThyroid C cellsParathyroidThymusHes1 homozygous null mutant miceWnt1-Cre/R26R transgenic mice
英文摘要: Abstract(#br)Hes genes are required to maintain diverse progenitor cell populations during embryonic development. Loss of Hes1 results in a spectrum of malformations of pharyngeal endoderm-derived organs, including the ultimobranchial body (progenitor of C cells), parathyroid, thymus and thyroid glands, together with highly penetrant C-cell aplasia (81%) and parathyroid aplasia (28%). The hypoplastic parathyroid and thymus are mostly located around the pharyngeal cavity, even at embryonic day (E) 15.5 to E18.5, indicating the failure of migration of the organs. To clarify the relationship between these phenotypes and neural crest cells, we examine fate mapping of neural crest cells colonized in pharyngeal arches in Hes1 null mutants by using the Wnt1-Cre/R26R reporter system. In null...
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影响因子:3.677 (2012)

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关键词翻译
关键词翻译
  • pharyngeal 咽的
  • survival 生存
  • mesenchymal 间叶细胞的
  • crest 
  • required 必需
  • cells 麻风细胞
  • organs 男生殖器
  • derived 导生的
  • development 开发
  • neural 神经系统的