Utilization of Gene Expression Signature for Quality Control of Traditional Chinese Medicine Formula Si-Wu-Tang
作者: Chen XieZhijun WangCharles WangJun XuZhining WenHaitian WangLeming ShiMoses S. S. ChowYing HuangZhong Zuo
作者单位: 1School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
2Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences
3National Center for Toxicological Research, U.S. Food and Drug Administration
4Functional Genomics Core, Beckman Research Institute, City of Hope Comprehensive Cancer Center
5Clinical Transcriptional Genomics Core, Medical Genetics Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA
6Department of Clinical Pharmacy and Center for Pharmacogenomics, School of Pharmacy, Fudan University
7College of Chemistry, Sichuan University
8Division of Biostatistics, School of Public Health and Primary Care, The Chinese University of Hong Kong
刊名: The AAPS Journal, 2013, Vol.15 (3), pp.884-892
来源数据库: Springer Journal
DOI: 10.1208/s12248-013-9491-5
关键词: gene expression signaturepharmacokineticsquality controlSi-Wu-Tangtraditional Chinese medicine
英文摘要: Abstract(#br)The current study utilized a combined pharmacokinetic and genomic approach to demonstrate the feasibility of a new quality control method by using a panel of special differentially expressed genes (DEGs) as unique fingerprint to serve as marker of in vivo bioactivity for a representative traditional Chinese medicine (TCM) formula, Si-Wu-Tang (SWT). The method involves firstly obtaining possible in vivo active components, i.e. , the “absorbable” components from the permeate of the Caco-2 monolayer model to simulate oral administration of two specific SWT products (CU-SWT, J-SWT), their component single herbs (Angelicae, Chuanxiong, Paeoniae, and Rehmanniae), and a standard mixture of active compounds (ferulic acid, ligustilide, senkyunolide A). Then, these respective...
全文获取路径: Springer  (合作)
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影响因子:4.386 (2012)

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