Effect of thimerosal on the neurodevelopment of premature rats
作者: Yan-Ni ChenJue WangJie ZhangSu-Jiao LiLi HeDong-Dong ShaoHui-Ying Du
作者单位: 1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University
2Affiliated Xi’an Children’s Hospital of Medical College of Xi’an Jiaotong University
刊名: World Journal of Pediatrics, 2013, Vol.9 (4), pp.356-360
来源数据库: Springer Journal
DOI: 10.1007/s12519-013-0443-z
关键词: dopamine D4 receptorneurodevelopmentserotonin 2A receptorthimerosal
英文摘要: Abstract(#br) Background(#br)This study was undertaken to determine the effect of thimerosal on the neurodevelopment of premature rats.(#br) Methods(#br)Thimerosal was injected into premature SD rats at a dose of 32.8, 65.6, 98.4 or 131.2 μg/kg on postnatal day 1. Expression of dopamine D4 receptor (DRD4) and serotonin 2A receptor (5-HT2AR), apoptosis in the prefrontal cortex on post-injection day 49, and learning and memory function were studied and compared with those in a control group injected with saline.(#br) Results(#br)Expression of DRD4 and 5-HT2AR and learning function decreased, and apoptosis increased significantly in the 131.2 μg/kg group ( P <0.001). Memory function was significantly impaired by 65.6 ( P <0.05), 98.4 and 131.2 μg/kg ( P <0.001).(#br) Conclusions(#br)The...
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影响因子:1.084 (2012)

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关键词翻译
关键词翻译
  • thimerosal 乙基汞硫代水杨酸钠
  • premature 早熟的