Deconvoluting the Obesity and Breast Cancer Link: Secretome, Soil and Seed Interactions
作者: Nikki A. FordKaylyn L. DevlinLaura M. LashingerStephen D. Hursting
作者单位: 1Department of Nutritional Sciences, University of Texas at Austin
2Institute for Cellular and Molecular Biology, University of Texas at Austin
3Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
4Dell Pediatric Research Institute
刊名: Journal of Mammary Gland Biology and Neoplasia, 2013, Vol.18 (3-4), pp.267-275
来源数据库: Springer Nature Journal
DOI: 10.1007/s10911-013-9301-9
关键词: ObesityBreast cancerLeptinInsulinInflammationp53
英文摘要: Abstract(#br)Obesity is associated with increased risk of breast cancer in postmenopausal women and is linked with poor prognosis in pre- and postmenopausal breast cancer patients. The mechanisms underlying the obesity-breast cancer connection are becoming increasingly clear and provide multiple opportunities for primary to tertiary prevention. Several obesity-related host factors can influence breast tumor initiation, progression and/or response to therapy, and these have been implicated as key contributors to the complex effects of obesity on cancer incidence and outcomes. These host factors include components of the secretome, including insulin, insulin-like growth factor-1, leptin, adiponectin, steroid hormones, cytokines, vascular regulators, and inflammation-related molecules, as...
全文获取路径: Springer Nature  (合作)

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