Ephrin Receptor (Eph) -A1, -A2, -A4 and -A7 Expression in Mobile Tongue Squamous Cell Carcinoma: Associations with Clinicopathological Parameters and Patients Survival
作者: Stamatios TheocharisJerzy KlijanienkoConstantinos GiaginisParaskevi AlexandrouEfstratios PatsourisXavier Sastre-Garau
作者单位: 1Department of Pathology, Institut Curie
2First Department of Pathology, Medical School, National and Kapodistrian University of Athens
3Department of Food Science and Nutrition, University of the Aegean
刊名: Pathology & Oncology Research, 2014, Vol.20 (2), pp.277-284
来源数据库: Springer Journal
DOI: 10.1007/s12253-013-9692-3
关键词: Mobile tongue squamous cell carcinomaEphrin receptorsClinicopathological parametersPrognosisImmunohistochemistry
英文摘要: Abstract(#br)Ephrin receptors (Ephs) are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate the clinical significance of Eph-A1, -A2, -A4 and -A7 protein expression in mobile tongue squamous cell carcinoma (SCC). Eph-A1, -A2, -A4 and -A7 protein expression was assessed immunohistochemically on 37 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics, overall and disease-free patients’ survival. All the examined mobile tongue SCC cases were found positive for Eph-A1, -A2, -A4 and -A7. Significant associations were noted between high Eph-A1, -A4 and -A7 expression and absence of lymph node metastases ( p = 0.0263,...
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影响因子:1.555 (2012)

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  • A2 主动脉瓣第二音