Assessment of combined antiandrogenic effects of binary parabens mixtures in a yeast-based reporter assay
作者: Dehua MaLujun ChenXiaobiao ZhuFeifei LiCong LiuRui Liu
作者单位: 1School of Environment, Tsinghua University
2Zhejiang Provincial Key Laboratory of Water Science and Technology
刊名: Environmental Science and Pollution Research, 2014, Vol.21 (10), pp.6482-6494
来源数据库: Springer Journal
DOI: 10.1007/s11356-014-2497-4
关键词: Endocrine disrupting chemicalsAntiandrogenCombined effectParabensN-propylparabenIsoboles
英文摘要: Abstract(#br)To date, toxicological studies of endocrine disrupting chemicals (EDCs) have typically focused on single chemical exposures and associated effects. However, exposure to EDCs mixtures in the environment is common. Antiandrogens represent a group of EDCs, which draw increasing attention due to their resultant demasculinization and sexual disruption of aquatic organisms. Although there are a number of in vivo and in vitro studies investigating the combined effects of antiandrogen mixtures, these studies are mainly on selected model compounds such as flutamide, procymidone, and vinclozolin. The aim of the present study is to investigate the combined antiandrogenic effects of parabens, which are widely used antiandrogens in industrial and domestic commodities. A yeast-based human...
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影响因子:2.618 (2012)

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关键词翻译
关键词翻译
  • parabens 对羟基苯甲酸脂类
  • mixtures 混合料
  • combined 组合
  • yeast 酵母
  • reporter 报告生成程序
  • effects 海员自身物品
  • based 基于
  • binary 二元的
  • assay 试金