Extracellular signal-regulated kinase (ERK) expression and activation in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
作者: Stamatios TheocharisIoly Kotta-LoizouJerzy KlijanienkoConstantinos GiaginisParaskevi AlexandrouEougken DanaJose RodriguezEfstratios PatsourisXavier Sastre-Garau
作者单位: 1Department of Pathology, Institut Curie
2First Department of Pathology, Medical School, National and Kapodistrian University of Athens
3Department of Food Science and Nutrition, University of the Aegean
4Department of Head and Neck Surgery, Institut Curie
刊名: Tumor Biology, 2014, Vol.35 (7), pp.6455-6465
来源数据库: Springer Journal
DOI: 10.1007/s13277-014-1853-9
关键词: Mobile tongue squamous cell carcinomaERK1p-ERK1/2Clinicopathological parametersPrognosisImmunohistochemistry
英文摘要: Abstract(#br)Extracellular signal-regulated kinase (ERK) has been considered as a critical regulator of diverse cellular processes such as proliferation, survival and motility, being implicated in the malignant transformation in several tissue types. The present study aimed to evaluate the clinical significance of total ERK1 (t-ERK1) and phosphorylated ERK1/2 (p-ERK1/2) protein expression in mobile tongue squamous cell carcinoma (SCC). t-ERK1 and p-ERK1/2 protein expression in tumour cells and infiltrating the tumour microenvironment lymphoid cells was assessed immunohistochemically on 47 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics, overall and disease-free patients’ survival. Enhanced nuclear t-ERK1 and p-ERK1/2 expression in...
全文获取路径: Springer  (合作)
影响因子:2.518 (2012)

  • squamous 具鳞的
  • survival 生存
  • carcinoma 癌症
  • tongue 岩舌
  • expression 表示
  • activation 活化
  • kinase 激酶
  • regulated 规定
  • parameters 参数
  • mobile 可动的