Annexin A1 in primary tumors promotes melanoma dissemination
作者: Zied BoudhraaFabien RondepierreLemlih OuchchaneRoselyne KintossouAnna TrzeciakiewiczFrederic FranckJean KanitakisBruno LabeilleJuliette Joubert-ZakeyhBernadette BouchonJean Luc PerrotSandrine MansardJanine PaponPierre DechelotteJean-Michel ChezalElisabeth Miot-NoiraultMathilde BonnetMichel D’IncanFrançoise Degoul
作者单位: 1Clermont-Ferrand Université, Université d’Auvergne, INSERM U990, Imagerie Moléculaire et Thérapie Vectorisée
2Department of Biostatistics, Université d’Auvergne
3Department of Dermatology, CHU, Université d’Auvergne
4Department of Pathology, CHU, Université d’Auvergne
5Department of Dermatopathology, Edouard Herriot Hospital Group
6Department of Dermatopathology, CHU St-Etienne
刊名: Clinical & Experimental Metastasis, 2014, Vol.31 (7), pp.749-760
来源数据库: Springer Journal
DOI: 10.1007/s10585-014-9665-2
关键词: Annexin A1Formyl peptide receptorsMelanomaMetastases
英文摘要: Abstract(#br)Metastatic melanoma is one of the most aggressive forms of skin cancer and has a poor prognosis. We have previously identified Annexin A1 (ANXA1) as a potential murine melanoma-spreading factor that may modulate cell invasion by binding to formyl peptide receptors (FPRs). Here, we report that (1) in a B16Bl6 spontaneous metastasis model, a siRNA-induced decrease in tumoral ANXA1 expression significantly reduced tumoral MMP2 activity and number of lung metastases; (2) in a retrospective study of 61 patients, metastasis-free survival was inversely related to ANXA1 expression levels in primary tumors (HR 3.15 [1.03–9.69], p = 0.045); (3) in human melanoma cell lines, ANXA1 level was positively correlated with in vitro invasion capacity whereas normal melanocytes contained low...
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影响因子:3.46 (2012)

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关键词翻译
关键词翻译
  • dissemination 散布
  • melanoma 黑瘤
  • primary 一次的